ESCRT-I Complex Regulates Cell Death (P16385)

Target Name: ESCRT-I complex

NCBI ID: P16385

ESCRT-I complex

Other Name(s): ESCRT-I | Endosomal sorting complex required for transport I

ESCRT-I Complex Regulates Cell Death

ESCRT-I complex is a protein that plays a critical role in cell death regulation. It is a complex of five proteins: ESCRT-I, ESCRT-II, ESCRT-III, ESCRT-IV, and ESCRT-V. ESCRT-I is the core protein of the complex and is responsible for the formation of the ESCRT-I complex.

The ESCRT-I complex is involved in the regulation of cell death, which is a natural and essential process in the life of all living organisms. Cell death is a normal part of the cell cycle and is regulated by a variety of factors, including the environment, the DNA damage response, and signaling pathways. ESCRT-I plays a key role in these processes by ensuring that cells are properly equipped to respond to stress and damage and that they are able to navigate the process of cell death.

ESCRT-I complex is composed of five proteins that work together to regulate cell death. The first protein is ESCRT-I, which is the core protein of the complex. It is a 22-kDa protein that is involved in the formation of the complex. ESCRT-I is able to form a stable complex with other proteins in the ESCRT-I complex, including ESCRT-II, ESCRT-III, ESCRT-IV, and ESCRT-V.

The second protein in the ESCRT-I complex is ESCRT-II, which is a 14-kDa protein that is involved in the regulation of cell cycle progression. ESCRT-II is able to interact with ESCRT-I and with other proteins in the complex, including the transcription factor p53. This interaction between ESCRT-II and p53 allows for the regulation of cell cycle progression and the prevention of cell proliferation.

The third protein in the ESCRT-I complex is ESCRT-III, which is a 19-kDa protein that is involved in the regulation of mitochondrial function. ESCRT-III is able to interact with ESCRT-I and with other proteins in the complex, including the mitochondrial protein Drp1. This interaction between ESCRT-III and Drp1 allows for the regulation of mitochondrial function and the prevention of mitochondrial dysfunction.

The fourth protein in the ESCRT-I complex is ESCRT-IV, which is a 16-kDa protein that is involved in the regulation of the actin cytoskeleton. ESCRT-IV is able to interact with ESCRT-I and with other proteins in the complex, including the actin protein F-actin. This interaction between ESCRT-IV and F-actin allows for the regulation of actin cytoskeleton structure and the prevention of actin-related diseases.

The final protein in the ESCRT-I complex is ESCRT-V, which is a 12-kDa protein that is involved in the regulation of the endoplasmic reticulum. ESCRT-V is able to interact with ESCRT-I and with other proteins in the complex, including the transmembrane protein Zyx. This interaction between ESCRT-V and Zyx allows for the regulation of endoplasmic reticulum function and the prevention of endoplasmic reticulum-related diseases.

In conclusion, ESCRT-I complex is a protein that plays a critical role in cell death regulation. It is composed of five proteins that work together to ensure that cells are properly equipped to respond to stress and damage and are able to navigate the process of cell death. ESCRT-I is the core protein of the complex and is responsible for the formation of the complex. ESCRT-

Protein Name: ESCRT-I Complex

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